Affiliate Lesson Plan

CCAGTACTGAACTAGGGGCAGCTGGGCTCCAGAGTCCCTCGGGTCTCAGGTCATGGCGGTCGCGGGGCCC GCGCCCGGAGCTGGCGCCAGGCCCAGGTTAGATCTGCAATTTCTCCAGCGGTTCCTGCAGATACTGAAGG TTTTGTTTCCTTCTTGGTCATCACAAAATGCCTTGATGTTCCTGACCCTTTTGTGCCTGACCCTACTGGA GCAATTTGTGATCTACCAGGTTGGCTTGATCCCCAGTCAGTACTATGGGGTCCTGGGAAACAAAGACTTG GAAGGGTTTAAGACTCTGACATTCCTGGCTGTCATGCTCATTGTTCTGAACTCCACGCTGAAGAGCTTTG ATCAGTTCACCTGCAACCTGCTGTATGTGAGCTGGAGGAAGGACCTCACTGAGCACCTTCACCGCCTCTA CTTCCGGGGCCGTGCGTACTACACCCTCAACGTGCTGCGGGATGACATCGATAACCCGGACCAGCGCATC AGCCAGGACGTGGAGCGATTCTGCCGGCAGCTCAGCAGCATGGCCAGCAAGCTCATCATCTCCCCGTTCA CCCTCGTCTACTACACTTACCAGTGCTTCCAAAGCACAGGCTGGCTCGGGCCTGTGAGCATCTTCGGGTA TTTCATCCTGGGGACCGTGGTGAACAAAACTTTGATGGGCCCCATTGTGATGAAGCTGGTGCATCAGGAG AAGCTGGAGGGAGATTTTAGGTTCAAGCACATGCAGATTCGGGTGAATGCGGAGCCTGCTGCTTTCTACA GAGCTGGGCATGTGGAGCACATGAGGACAGACCGCAGGCTGCAGAGACTCCTTCAGACCCAGAGGGAGCT GATGTCCAAGGAGCTCTGGCTGTACATCGGCATCAACACCTTTGACTATCTGGGCAGCATCCTGAGTTAC GTTGTCATCGCAATCCCCATTTTCAGCGGGGTCTATGGAGACCTGAGTCCCGCAGAGCTTAGCACCCTGG TCAGCAAGAATGCCTTTGTGTGCATCTACCTCATCAGCTGCTTCACCCAGCTCATCGACCTGTCCACGAC GCTCTCAGATGTGGCTGGCTACACGCACAGAATTGGGCAGCTTCGGGAGACGCTTCTGGACATGTCCCTG AAGTCACAGGACTGCGAGATCCTGGGCGAGAGCGAGTGGGGCTTGGACACACCCCCAGGGTGGCCAGCGG CAGAGCCAGCAGACACAGCATTTCTCCTTGAGCGGGTCTCCATCTCTGCCCCCTCCTCTGACAAACCCCT AATCAAGGATCTGAGCCTAAAGATCTCCGAGGGACAGAGCCTGCTCATCACAGGCAACACGGGCACTGGC AAGACCTCCTTGCTCCGGGTTCTGGGTGGCCTCTGGACGAGTACACGGGGCTCAGTGCAGATGCTGACGG ACTTTGGGCCCCATGGGGTGCTATTCCTGCCACAAAAGCCATTCTTCACTGACGGGACCCTTCGGGAGCA GGTCAGTCTAGTTCAGGGGGCTCACTCCTCCCTCCTCAACCCCGCCCACCCACAGCTGGGACCTCTGGCA CTGTGACAAGTCTCAGGTCCTAGAGTCAGGGCAAAAGGTGAGGTGGTGAAGTGGCCCGGGCCTGGGAACT GCTGGCTCTAAGAACCTTCTATTCACATCCATGGATTGGGCCCACTACTCATAGCAGCTCCTGAGGCAGG TAAATGGGGCAAGGACTCACGCCAAATACCACACGCGTATGTCAAACACCCAAGGTCGGATTCTGGGGCC CCTGCCCTCAGGAGGCTGTCAGACTGTTCCCCCTAAACACACTTCTGAAGGTTGTAGGGACCTTGCCCTG CTGTCTGCCGGCCAGAGCCTCTCCCATCTGACCCAGGCCAGGCGTTCCCACCTCTCCTCCTTGGGAGGTT CCAGTGGGTTCTGGAGGGAGGGTGGGCTGTGTGCAGCTCCGTCTTTTGCTCGCCCTCCTAGGTTGGTGTG GTTTTTTTCTTTTCTCAGGTGATATATCCCCTGAAGGAGGTCTACCCCGACTCAGGTTCTGCCGATGATG AGAGGATCTTGAGGTTCTTGGAATTGGCAGGCCTGTCCAACTTGGTGGCAAGGACAGAGGGCCTGGACCA GCAGGTGGACTGGAACTGGTATGATGTTCTGTCCCCGGGGGAGATGCAACGGCTCTCCTTTGCCCGACTC TTCTACCTGCAGCCGAAGTACGCAGTGCTTGATGAAGCCACCAGTGCCCTGACAGAGGAAGTGGAGAGCG AGCTCTATCGCATCGGCCAGCAGCTGGGGATGACGTTCATCAGTGTGGGACATCGGCAGAGCCTTGAGAA GTTTCATTCCTTGGTTCTGAAACTCTGTGGAGGAGGAAGATGGGAGCTGATGAGAATCAAAGTGGAATGA AGCTCTGGCTTTTGGAAGGAGAGCCACACTGTGGCGGGTCGGCGGCCCTCAGGAGAGACCAGGAGGACTG ACAGCGAAGATCGAGCTCAGGTTCGCCACATAGATCCCGTGCAGGAGCCACATGGGTCCTGTGCAGGACC CCTAGCAGTGGTGGGCTGAGCCCAGGTCTAGGTTTCTGTGGGGGACACTGAATCTCCCAGTGTTCAGTCT CCCAGGACTCTGCTGCCTCAGCCAGAGCCTCCATATGCTTGAAGTGCTGATTACCTACAAATGATTTCAG ATCATGTTTGCTAAAGAGAAATCTGGAAGTGTGAGATCTGTAAGAAATGAAAGAAATGACTCTTGGAGTC AAGAGATCTGGAAATCTTTTAATCAGTTAAATTGTGCAGCAATAGATTTTTAACTTTAACTGACCATTTA AGTTTTTTAATAAGTTTTTTACAAAGAAAAGTTAAACATTAAAAAGAATTACAGCTTTCTGTCTTCTCTA TCATGGAATGATCTTTTTTATTGAATCTCCAGATTTGTATTTGACAGCTTGGTGGGAAGGGAAGCACACT CTGCTGTTCTGGAATCTTATGCCCAGGGTTTTTCACTTCTCCCCACATCTCCCTTTCCACTTGCCAGTGT TGTGTAGTTAGAACCTGAACCACTAACTTCCAGGGGCCTTTGGTCTGCCCTACCTTAACCCAAATGAAAG TAAATCCCTTTCCCCTTAGCCAAAATAAGGTTGGGTTTTCTAAAAAAATAGTCTATATTAGGGAACAACA ACAGCAAATTAGACAAAACCCAGAAAGCACAAAGCATGAGGTGGAGTTACTGTGCCCAAAGTCCTCACTC AGACCAGTGCCCCTCCAGTTCAGTTGTCTATGTATTACCTTCCTTACCTTCATAATTTTTGCCAGGCTTC TGTACTTCTAGTACTTGAGTTACTTAATATTTTTAAAAACAAACCTTTTAAGTTTAAATGGATTTTTAAG TGAAATTTTACACTTAACATAGATGGAAAGTAACTAAAAATAAATACAAGAAAAACAAAAAAAAAAAAAA AAAAA

Sequence #1 belongs to ATP-binding cassette, sub-family D (ALD) peroxisomal membrane protein-1-like protein (PXMP1-L) gene encoding a peroxisomal ABC transporter, chromosome="14"/map="14q24.3"

Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing of this gene by exon deletion and retained introns results in five observed products.

GCGGACGGACGCGCCTGGTGCCCCGGGGAGGGGCGCCACCGGGGGAGGAGGAGGAGGAGAAGGTGGAGAG GAAGAGACGCCCCCTCTGCCCGAGACCTCTCAAGGCCCTGACCTCAGGGGCCAGGGCACTGACAGGACAG GAGAGCCAAGTTCCTCCACTTGGGCTGCCCGAAGAGGCCGCGACCCTGGAGGGCCCTGAGCCCACCGCAC CAGGGGCCCCAGCACCACCCCGGGGGCCTAAAGCGACAGTCTCAGGGGCCATCGCAAGGTTTCCAGTTGC CTAGACAACAGGCCCAGGGTCAGAGCAACAATCCTTCCAGCCACCTGCCTCAACTGCTGCCCCAGGCACC AGCCCCAGTCCCTACGCGGCAGCCAGCCCAGGTGACATGCCGGTGCTCTCCAGGCCCCGGCCCTGGCGGG GGAACACGCTGAAGCGCACGGCCGTGCTCCTGGCCCTCGCGGCCTATGGAGCCCACAAAGTCTACCCCTT GGTGCGCCAGTGCCTGGCCCCGGCCAGGGGTCTTCAGGCGCCCGCCGGGGAGCCCACGCAGGAGGCCTCC GGGGTCGCGGCGGCCAAAGCTGGCATGAACCGGGTATTCCTGCAGCGGCTCCTGTGGCTCCTGCGGCTGC TGTTCCCCCGGGTCCTGTGCCGGGAGACGGGGCTGCTGGCCCTGCACTCGGCCGCCTTGGTGAGCCGCAC CTTCCTGTCGGTGTATGTGGCCCGCCTGGACGGAAGGCTGGCCCGCTGCATCGTCCGCAAGGACCCGCGG GCTTTTGGCTGGCAGCTGCTGCAGTGGCTCCTCATCGCCCTCCCTGCTACCTTCGTCAACAGTGCCATCC GTTACCTGGAGGGCCAACTGGCCCTGTCGTTCCGCAGCCGTCTGGTGGCCCACGCCTACCGCCTCTACTT CTCCCAGCAGACCTACTACCGGGTCAGCAACATGGACGGGCGGCTTCGCAACCCTGACCAGTCTCTGACG GAGGACGTGGTGGCCTTTGCGGCCTCTGTGGCCCACCTCTACTCCAACCTGACCAAGCCACTCCTGGACG TGGCTGTGACTTCCTACACCCTGCTTCGGGCGGCCCGCTCCCGTGGAGCCGGCACAGCCTGGCCCTCGGC CATCGCCGGCCTCGTGGTGTTCCTCACGGCCAACGTGCTGCGGGCCTTCTCGCCCAAGTTCGGGGAGCTG GTGGCAGAGGAGGCGCGGCGGAAGGGGGAGCTGCGCTACATGCACTCGCGTGTGGTGGCCAACTCGGAGG AGATCGCCTTCTATGGGGGCCATGAGGTGGAGCTGGCCCTGCTACAGCGCTCCTACCAGGACCTGGCCTC GCAGATCAACCTCATCCTTCTGGAACGCCTGTGGTATGTTATGCTGGAGCAGTTCCTCATGAAGTATGTG TGGAGCGCCTCGGGCCTGCTCATGGTGGCTGTCCCCATCATCACTGCCACTGGCTACTCAGAGTCAGATG CAGAGGCCGTGAAGAAGGCAGCCTTGGAAAAGAAGGAGGAGGAGCTGGTGAGCGAGCGCACAGAAGCCTT CACTATTGCCCGCAACCTCCTGACAGCGGCTGCAGATGCCATTGAGCGGATCATGTCGTCGTACAAGGAG GTGACGGAGCTGGCTGGCTACACAGCCCGGGTGCACGAGATGTTCCAGGTATTTGAAGATGTTCAGCGCT GTCACTTCAAGAGGCCCAGGGAGCTAGAGGACGCTCAGGCGGGGTCTGGGACCATAGGCCGGTCTGGTGT CCGTGTGGAGGGCCCCCTGAAGATCCGAGGCCAGGTGGTGGATGTGGAACAGGGGATCATCTGCGAGAAC ATCCCCATCGTCACGCCCTCAGGAGAGGTGGTGGTGGCCAGCCTCAACATCAGGGTGGAGGAAGGCATGC ATCTGCTCATCACAGGCCCCAATGGCTGCGGCAAGAGCTCCCTGTTCCGGATCCTGGGTGGGCTCTGGCC CACGTACGGTGGTGTGCTCTACAAGCCCCCACCCCAGCGCATGTTCTACATCCCGCAGAGGCCCTACATG TCTGTGGGCTCCCTGCGTGACCAGGTGATCTACCCGGACTCAGTGGAGGACATGCAAAGGAAGGGCTACT CGGAGCAGGACCTGGAAGCCATCCTGGACGTCGTGCACCTGCACCACATCCTGCAGCGGGAGGGAGGTTG GGAGGCTATGTGTGACTGGAAGGACGTCCTGTCGGGTGGCGAGAAGCAGAGAATCGGCATGGCCCGCATG TTCTACCACAGGCCCAAGTACGCCCTCCTGGATGAATGCACCAGCGCCGTGAGCATCGACGTGGAAGGCA AGATCTTCCAGGCGGCCAAGGACGCGGGCATTGCCCTGCTCTCCATCACCCACCGGCCCTCCCTGTGGAA ATACCACACACACTTGCTACAGTTCGATGGGGAGGGCGGCTGGAAGTTCGAGAAGCTGGACTCAGCTGCC CGCCTGAGCCTGACGGAGGAGAAGCAGCGGCTGGAGCAGCAGCTGGCGGGCATTCCCAAGATGCAGCGGC GCCTCCAGGAGCTCTGCCAGATCCTGGGCGAGGCCGTGGCCCCAGCGCATGTGCCGGCACCTAGCCCGCA AGGCCCTGGTGGCCTCCAGGGTGCCTCCACCTGACACAACCGTCCCCGGCCCCTGCCCCGCCCCCAAGCT CGGATCACATGAAGGAGACAGCAGCACCCACCCATGCACGCACCCCGCCCCTGCATGCCTGGCCCCTCCT CCTAGAAAACCCTTCCCGCCCTCGGGAAAGTAGATGTGGAGGGTGGCGCCCTGCGTAACCCTCGCCCTGT CCCTCCCACTCCCTGGGGGCGCTGTTCCACAGTGACTGGGCCCTGTCCAGGGCAGTGAGTCCTCTACTTT GCTCCGCGGAGGAAGCTGGGGTACAAGGGGCCCAGTGCTGGCCACACAGCAGCGCAGCCGAGCCCCAGGA GCCCGTCAGGCCACAGCCCCTGGCACTGCAGGTGGCCTCCCTCCAGAGACTCGAGTCCCCATGATTCCCT CCTCGTCAGTCTCTCAAAGACCCCATGGTCCATCCCCTGAGGGTGGTCAGCCAAGGCTCCCGTTCCGTGG GATGCCATAAAAGCCGCCCAGTGGGACCCACAGTCACACAGAGCGCCTCACCTGCATCCTCTCCCCCACA AGAGCCCCAAAGATCCCACGGGAGAGGGGAGAGGGACGCACAGCACTGCCTGCCAAGCGAGAATGCAGGC CCCGCCCCCTCGGCCCCTCACCACCTCTTTCTACAGCCTAATTTATTGGATTCCCTATTCGTAGCCATCT CCGTGGCCAATGTGACTACCGTGCCAGCAGCGGGGGCGGCCCAGCCTCTGAGTCCCGTGGGGCCCCGGCT CCCACCGGTGCCAAACCCAGCCCCTGCGGCCGTCACCCCGCCAGCCTACACTGCCAGCCGCCACCGGGGC ACACGGGCCTCTGCTTGCCAGCCAGGAGTGCGGACACCATGTTCCCAGCTCAGTGCCAAAGAGGGGTCAC CAGGGGGAGCTGTCTGCGGAGCCAGCGCCTGCCCGAGAGAGACCCCACCGCCACCGTGTGCCTTTCCCGG GCCCTCAGCCCTCGGGCCGGGCACCACCCCCAGTCCCCCCAGTAAA

Sequence #2 belongs to ATP-binding cassette, sub-family D (ALD) member 1 (Gene ABCD 1) ABCD1 (ALDP) maps to Xq28 and is mutated in the X-linked disorder adrenoleukodystrophy (ALD; 300100). ABCD1 is a member of the ATP-binding cassette (ABC) transporter superfamily. The superfamily contains membrane proteins that translocate a wide variety of substrates across extra- and intracellular membranes, including metabolic products, lipids and sterols, and drugs.

GTTTTGTTCGCTTGGAAATCTCCCTTTCTGCTTGCTCTTCTGTTTGCGGTATCTACTTGAAATCTTACCG AAGTGATGTATATTCTTGAAACTTCTGTGGGTTTCTAAGTGACACTTGAGCATGCTCCAGTAGCTAGAGC CGGTTTTGTTCGCCAGCAGATGGCCTGATTCGACCTCTCCAAAAATAGACATTTTAACTCTCTGAACTCC TGTTTAAGGAAGGATGTAATTCGCTTTGCTCTCTCCTCATTTTCAAGGTTCAAAGGGAAGCTGCGAGGAT TCCAAGGTCCCACCGCCCTCACAGCCAATGAGGGGCCTGGGAGGGAGGAGCTTGGTGCAGCTTGAGCTTC TGAGAGAATCATTCCCGGTAGATGCAGCGGAGTCTGAGCTCTGCTGCATCTGTCACAGCAGAACAAAATT AAAAACACAACAGTGGAAGAGAAACGCTGCAGACTATGGGACGCTGTAGGACTTTCTAAAACATTTGCTG GGGATTTCTGTGAAGCATGATCTTTTAAAACGAATTCTTTTGGAAGCCGGTTTGGGTAACTGGGAAAATG ACACATATGCTAAATGCAGCAGCTGATCGAGTGAAATGGACCAGATCGAGTGCTGCTAAGAGGGCTGCCT GCCTGGTGGCTGCGGCATATGCTCTGAAAACCCTCTATCCCATCATTGGCAAGCGTTTAAAGCAATCTGG CCACGGGAAGAAAAAAGCAGCAGCTTACCCTGCTGCAGAGAACACAGAAATACTGCATTGCACCGAGACC ATTTGTGAAAAACCTTCGCCTGGAGTGAATGCAGATTTCTTCAAACAGCTACTAGAACTTCGGAAAATTT TGTTTCCAAAACTTGTGACCACTGAAACAGGGTGGCTCTGCCTGCACTCAGTGGCTCTAATCTCAAGAAC CTTTCTTTCTATCTATGTGGCTGGTCTGGATGGAAAAATCGTGAAAAGCATTGTGGAAAAGAAGCCTCGG ACTTTCATCATCAAATTAATCAAGTGGCTTATGATTGCCATCCCTGCTACCTTCGTCAACAGTGCAATAA GGTACCTGGAATGCAAATTGGCTTTGGCCTTCAGAACTCGCCTAGTAGACCACGCCTATGAAACCTATTT TACAAATCAGACTTATTATAAAGTGATCAATATGGATGGGAGGCTGGCAAACCCTGACCAATCTCTTACG GAGGATATTATGATGTTCTCCCAATCTGTGGCTCACTTGTATTCCAATCTGACCAAACCTATTTTAGATG TAATGCTGACCTCCTATACACTCATTCAAACTGCTACATCCAGAGGAGCAAGCCCAATTGGGCCCACCCT ACTAGCAGGACTTGTGGTGTATGCCACTGCTAAAGTGTTAAAAGCCTGTTCTCCCAAATTTGGCAAACTG GTGGCAGAGGAAGCACATAGAAAAGGCTATTTGCGGTATGTGCACTCGAGAATTATAGCCAATGTAGAAG AAATTGCCTTTTACAGAGGACATAAGGTAGAAATGAAACAACTTCAGAAAAGTTACAAAGCTTTAGCAGA TCAGATGAACCTCATTTTATCCAAACGTTTGTGGTACATCATGATAGAACAGTTCCTGATGAAGTATGTT TGGAGCAGCAGTGGACTAATTATGGTGGCTATACCTATTATCACTGCAACTGGCTTTGCAGATGGTGAGG ATGGCCAAAAGCAAGTTATGGTTAGTGAACGGACAGAAGCCTTTACCACTGCTCGAAATTTACTGGCCTC TGGAGCTGATGCTATTGAAAGGATTATGTCTTCATACAAAGAGGTCACTGAATTAGCAGGCTACACTGCT CGAGTGTACAATATGTTTTGGGTCTTTGATGAAGTAAAAAGAGGCATTTATAAGAGAACTGCTGTCATTC AAGAATCTGAAAGCCATAGCAAGAATGGAGCTAAGGTAGAATTACCTCTCAGTGACACATTGGCAATTAA AGGAAAAGTTATTGATGTGGATCACGGAATTATTTGTGAAAATGTTCCCATAATTACACCAGCAGGAGAA GTGGTGGCTTCCAGGCTAAACTTCAAAGTAGAAGAAGGAATGCATCTTTTGATAACTGGTCCCAATGGTT GTGGGAAAAGTTCTCTCTTCAGAATTCTAAGTGGGCTCTGGCCTGTGTATGAAGGAGTCCTCTATAAACC ACCTCCTCAACATATGTTTTATATTCCACAAAGGCCATATATGTCTCTTGGAAGTCTTCGGGATCAAGTC ATTTACCCTGATTCAGTGGATGATATGCATGATAAAGGTTATACAGACCAAGATCTGGAACGTATCCTAC ACAATGTCCATCTCTATCACATAGTTCAAAGAGAAGGAGGATGGGATGCTGTTATGGACTGGAAAGATGT CCTGTCAGGAGGGGAAAAGCAAAGAATGGGCATGGCTCGTATGTTTTATCATAAACCAAAATATGCCTTG CTGGATGAATGTACCAGTGCTGTCAGCATTGATGTCGAAGGAAAGATATTTCAGGCTGCAAAAGGGGCTG GAATTTCCTTACTGTCTATAACACACAGACCTTCTCTTTGGAAATACCACACACATTTATTACAGTTTGA TGGTGAAGGAGGTTGGCGCTTTGAACAATTGGATACTGCTATCCGTTTGACATTGAGTGAAGAAAAACAA AAGCTAGAATCTCAGCTAGCTGGAATTCCCAAAATGCAGCAGAGACTCAATGAACTATGTAAAATTTTGG GAGAAGACTCAGTGCTGAAAACAATTAAAAATGAAGATGAGACATCTTAATTTGTTTTGACATATTTTAA AAAGTTAATTATTAGATAAAGGCTCAAAGACATTCTGTTATACTGCATGAAGTATGTTAAGCTAAGCACA GAGAAAAAAAGGCAGCAAGACATGTTTTATAAGATTTTAGCATTAAGGAAGTATATGATCTGACTTTTCA GAAGAAAATAAACAAATGCATTATGTAAGGTCAGTCATTATGACTTATACTAATTCCTAGTGAAGGCCTA ATGCACTTGTAAAACAGGATTTTCTAGGTGAATTCCTGATGAATACCAGATTTACTATGTATATGTGGTG TGTCTGAAGTTCTTAACAAACATGGGCAATATTCTGGAAATGAAACAAGTTATAACTGAGCACCATTTGG GTTGATACCAAGTGCATAAGATTCAAACTTTGAGTGACATTTAGTCCATTTATGGTTGATATTAGGTTTA ATACCTAGAATTCAAATTGATTATTGCTAGTGGCCAACTAAACCTGTACAAAATAGCTGACAGTTTTATA ACTAATTTCAATATAAAAATTGTTTTAATGGCATTTGTTGAAAGAAAAAAGCATGGCTAAAATGTATCAA ATGCCATATTTTTAAATTTTGGACTTTAAGCATCTTAATGAGGGCATATAACAAATTAATTTTAGTACAA TCTTAAATATTTTTAATAAATCCTTTCATTTTAAAAAGAGAATTGCCAATACAGAAAAGGAGTATCCAAA CAATGTCTCAACCTGATAATTTCCTTAGCAGAATTACCTATTGCAACTTCTGTTCAGAAATACACAGCTT GTTTTTTTGCCCAAGGATGAGTCTACATTTTAAGAACTGCAATGGTATAAAGGAACTTAAGGATTCTGAG AATCATAGTAATAACATACATTGGAATAGTACTTTATAATTTACAATCCCCATTTACATCATTTCACCTT AATGTTGAGGACAATGTTTTGAAACAAATACTATTTTTCCTACTTTGCTTTTGAGAAAATTGACACTCAG ACTTGCCCTAATCATGCACTTTACTTAAGGAAAGATCGAGAAATCAAATGAAGTTCTCCTGACTCTCTGG TTTAGTGCTCTTTTGTTATTATCCTTTAAATCAAACTGGGCTATAATAGCAATAAAAGTTAGACGAAGTG TAGAAAATAAAATAAATTTCATAATGTTAAAAAAAAAAAAAAAAAAAAA

Sequence #3 belongs to TP-binding cassette, sub-family D (ALD), member 2 (ABCD2)

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.

Chromosome="12"/map="12q11-q12"